Restorative Dentistry & Endodontics

Research Article

Is dentin biomodification with collagen cross-linking agents effective for improving dentin adhesion? A systematic review and meta-analysis: Julianne Coelho Silva, Edson Luiz Cetira Filho, Paulo Goberlânio de Barros Silva, Fábio Wildson Gurgel Costa, Vicente de Paulo Aragão Saboia; Restor Dent Endod 2022;47(2):e23. Published online May 6, 2022; DOI: https://doi.org/10.5395/rde.2022.47.e23

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Objectives

The aim of this investigation was to evaluate the effectiveness of collagen cross-linking agents (CCLAs) used in combination with the adhesive technique in restorative procedures.

Materials and Methods

In this systematic review, the authors followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. An electronic search was performed using PubMed, Scopus, Web of Science, Cochrane Library, LILACS, and DOSS, up to October 2020. The gray literature was also researched. Only randomized clinical trials were selected.

Results

The selection process yielded 3 studies from the 838 retrieved. The addition of CCLAs in the retention of restorations increased the number of events. The postoperative sensitivity scores and marginal adaptation scores showed no significant difference between the CCLA and control groups, and the marginal pigmentation scores showed a significant increase in the CCLA group. There were no caries events in any group throughout the evaluation period.

Conclusions

This systematic review showed that there is no clinical efficacy to justify the use of CCLAs in the protocols performed.

Citations

Citations to this article as recorded by

Riboflavin-ultraviolet-A collagen crosslinking treatments in improving dentin bonding and resistance to enzymatic digestion
Yung-Show Chiang, Ping-Ju Chen, Chun-Chan Ting, Yuh-Ling Chen, Shu-Fen Chuang
Journal of Dental Sciences.2025; 20(1): 109. CrossRef
Effect of dentin bio modifications and matrix metalloproteinase activity on bond strength – A systematic review and meta-analysis
D. Agarwal, S. R. Srinidhi, S. D. Aggarwal, P. Ingle, S. Tandon
Endodontics Today.2025; 23(1): 71. CrossRef
Stability of dentin matrix treated with caffeic acid phenethyl ester at different concentrations
Aline Honorato Damázio, Rosanna Tarkany Basting, Enrico Coser Bridi, Fabiana Mantovani Gomes França, Flávia Lucisano Botelho do Amaral, Cecilia Pedroso Turssi, Waldemir Francisco Vieira Junior, Roberta Tarkany Basting
Brazilian Journal of Oral Sciences.2024; 23: e244006. CrossRef
Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis
Louis Hardan, Umer Daood, Rim Bourgi, Carlos Enrique Cuevas-Suárez, Walter Devoto, Maciej Zarow, Natalia Jakubowicz, Juan Eliezer Zamarripa-Calderón, Mateusz Radwanski, Giovana Orsini, Monika Lukomska-Szymanska
Cells.2022; 11(15): 2417. CrossRef

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Review Article

Effects of matrix metallproteinases on dentin bonding and strategies to increase durability of dentin adhesion: Jung-Hyun Lee, Juhea Chang, Ho-Hyun Son; Restor Dent Endod 2012;37(1):2-8. Published online March 2, 2012; DOI: https://doi.org/10.5395/rde.2012.37.1.2

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The limited durability of resin-dentin bonds severely compromises the longevity of composite resin restorations. Resin-dentin bond degradation might occur via degradation of water-rich and resin sparse collagen matrices by host-derived matrix metalloproteinases (MMPs). This review article provides overview of current knowledge of the role of MMPs in dentin matrix degradation and four experimental strategies for extending the longevity of resin-dentin bonds. They include: (1) the use of broad-spectrum inhibitors of MMPs, (2) the use of cross-linking agents for silencing the activities of MMPs, (3) ethanol wet-bonding with hydrophobic resin, (4) biomimetic remineralization of water-filled collagen matrix. A combination of these strategies will be able to overcome the limitations in resin-dentin adhesion.

Citations

Citations to this article as recorded by

Remineralization Effects of Silver Fluoride, Silver Diamine Fluoride, and Sodium Fluoride Varnish
Jihyeon Lee, Hwalim Lee, Jongsoo Kim, Joonhaeng Lee, Jongbin Kim, Jisun Shin, Miran Han
International Journal of Clinical Preventive Dentistry.2024; 20(1): 19. CrossRef

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