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Review Articles
Silver nanoparticles in endodontics: recent developments and applications
Aysenur Oncu, Yan Huang, Gulin Amasya, Fatma Semra Sevimay, Kaan Orhan, Berkan Celikten
Restor Dent Endod 2021;46(3):e38.   Published online July 1, 2021
DOI: https://doi.org/10.5395/rde.2021.46.e38
AbstractAbstract PDFPubReaderePub

The elimination of endodontic biofilms and the maintenance of a leak-proof canal filling are key aspects of successful root canal treatment. Several materials have been introduced to treat endodontic disease, although treatment success is limited by the features of the biomaterials used. Silver nanoparticles (AgNPs) have been increasingly considered in dental applications, especially endodontics, due to their high antimicrobial activity. For the present study, an electronic search was conducted using MEDLINE (PubMed), the Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, and EMBASE. This review provides insights into the unique characteristics of AgNPs, including their chemical, physical, and antimicrobial properties; limitations; and potential uses. Various studies involving different application methods of AgNPs were carefully examined. Based on previous clinical studies, the synthesis, means of obtaining, usage conditions, and potential cytotoxicity of AgNPs were evaluated. The findings indicate that AgNPs are effective antimicrobial agents for the elimination of endodontic biofilms.

Citations

Citations to this article as recorded by  
  • Scoping review on the genotoxicity of silver nanoparticles in endodontics: therapeutic saviors or genetic saboteurs?
    Galvin Sim Siang Lin, Widya Lestari, Mohd Haikal Muhamad Halil, Mohd Syafiq Abd Aziz
    Odontology.2025; 113(2): 457.     CrossRef
  • Bioceramics in Endodontics: Limitations and Future Innovations—A Review
    Peramune Arachchilage Amila Saman Prasad Kumara, Paul Roy Cooper, Peter Cathro, Maree Gould, George Dias, Jithendra Ratnayake
    Dentistry Journal.2025; 13(4): 157.     CrossRef
  • Recent advances in antibacterial nanoformulations for endodontic applications
    Tiago Dionísio, Pedro Brandão, Vanessa Machado, João Botelho, José João Mendes, Pedro Fonte
    Expert Opinion on Drug Delivery.2025; : 1.     CrossRef
  • Systematic review of silver and vanadium-based antibiofilm agents: mechanisms and efficacy in oral biofilms
    João Marcos Carvalho-Silva, Andréa Cândido dos Reis
    Future Microbiology.2025; : 1.     CrossRef
  • Antimicrobial Effects of Formulations of Various Nanoparticles and Calcium Hydroxide as Intra-canal Medications Against Enterococcus faecalis: A Systematic Review
    Seema H Bukhari, Dax Abraham, Shakila Mahesh
    Cureus.2024;[Epub]     CrossRef
  • The Push-Out Bond Strength, Surface Roughness, and Antimicrobial Properties of Endodontic Bioceramic Sealers Supplemented with Silver Nanoparticles
    Karla Navarrete-Olvera, Nereyda Niño-Martínez, Idania De Alba-Montero, Nuria Patiño-Marín, Facundo Ruiz, Horacio Bach, Gabriel-Alejandro Martínez-Castañón
    Molecules.2024; 29(18): 4422.     CrossRef
  • Synergistic bactericidal activity of chlorhexidine loaded on positively charged ionic liquid-protected silver nanoparticles as a root canal disinfectant against Enterococcus faecalis: An ex vivo study
    Abbas Abbaszadegan, Elham Tayebikhorami, Ahmad Gholami, Nazanin Bonyanpour, Bahar Asheghi, Sara Nikmanesh
    Journal of Ionic Liquids.2024; 4(2): 100117.     CrossRef
  • Improving the Antimicrobial Potency of Berberine for Endodontic Canal Irrigation Using Polymeric Nanoparticles
    Célia Marques, Liliana Grenho, Maria Helena Fernandes, Sofia A. Costa Lima
    Pharmaceutics.2024; 16(6): 786.     CrossRef
  • A narrative review on application of metal and metal oxide nanoparticles in endodontics
    Roohollah Sharifi, Ahmad Vatani, Amir Sabzi, Mohsen Safaei
    Heliyon.2024; 10(15): e34673.     CrossRef
  • The Effectiveness of Silver Nanoparticles Mixed with Calcium Hydroxide against Candida albicans: An Ex Vivo Analysis
    Maha Alghofaily, Jood Alfraih, Aljohara Alsaud, Norah Almazrua, Terrence S. Sumague, Sayed H. Auda, Fahd Alsalleeh
    Microorganisms.2024; 12(2): 289.     CrossRef
  • Evaluation of the efficacy of a novel disinfecting material on the surface topography of gutta-percha: An in vitro study
    KHanisha Reddy, Lekshmi Chandran, TMurali Mohan, K Sudha, DL Malini, Bonney Dominic
    Journal of Conservative Dentistry.2023; 26(1): 94.     CrossRef
  • Silver Nanoparticles and Their Therapeutic Applications in Endodontics: A Narrative Review
    Farzaneh Afkhami, Parisa Forghan, James L. Gutmann, Anil Kishen
    Pharmaceutics.2023; 15(3): 715.     CrossRef
  • Nanopartículas antimicrobianas en endodoncia: Revisión narrativa
    Gustavo Adolfo Tovar Rangel , Fanny Mildred González Sáenz , Ingrid Ximena Zamora Córdoba , Lina María García Zapata
    Revista Estomatología.2023;[Epub]     CrossRef
  • Functionalized Nanoparticles: A Paradigm Shift in Regenerative Endodontic Procedures
    Vinoo Subramaniam Ramachandran, Mensudar Radhakrishnan, Malathi Balaraman Ravindrran, Venkatesh Alagarsamy, Gowri Shankar Palanisamy
    Cureus.2022;[Epub]     CrossRef
  • 1,659 View
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  • 12 Web of Science
  • 14 Crossref
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Endodontic biofilms: contemporary and future treatment options
Yeon-Jee Yoo, Hiran Perinpanayagam, Soram Oh, A-Reum Kim, Seung-Hyun Han, Kee-Yeon Kum
Restor Dent Endod 2019;44(1):e7.   Published online January 31, 2019
DOI: https://doi.org/10.5395/rde.2019.44.e7
AbstractAbstract PDFPubReaderePub

Apical periodontitis is a biofilm-mediated infection. The biofilm protects bacteria from host defenses and increase their resistance to intracanal disinfecting protocols. Understanding the virulence of these endodontic microbiota within biofilm is essential for the development of novel therapeutic procedures for intracanal disinfection. Both the disruption of biofilms and the killing of their bacteria are necessary to effectively treat apical periodontitis. Accordingly, a review of endodontic biofilm types, antimicrobial resistance mechanisms, and current and future therapeutic procedures for endodontic biofilm is provided.

Citations

Citations to this article as recorded by  
  • Evaluation of Anti-Biofilm Property of Zirconium Oxide Nanoparticles on Streptococcus mutans and Enterococcus faecalis: An In Vitro Study
    Anu Priya Guruswamy Pandian, Anil Kumar Ramachandran, Priyanka Kodaganallur Pitchumani, Blessy Mathai, Davis C Thomas
    Cureus.2025;[Epub]     CrossRef
  • Recent advances in antibacterial nanoformulations for endodontic applications
    Tiago Dionísio, Pedro Brandão, Vanessa Machado, João Botelho, José João Mendes, Pedro Fonte
    Expert Opinion on Drug Delivery.2025; : 1.     CrossRef
  • Self-Sacrificial Antibacterial Coating with Photothermal Response for Inhibiting Implant Infection
    Jinglin Zhang, Aijian Cao, Lizhen Chen, Dongliang Huo, Jingxian Zhang, Langhuan Huang, Shaozao Tan
    ACS Applied Nano Materials.2024; 7(23): 26907.     CrossRef
  • Biofilm in Endodontic Infection and its Advanced Therapeutic Options – An Updated Review
    Srilekha Jayakumar, Dinesh Sridhar, Bindu M. John, Karthikeyan Arumugam, Prashanth Ponnusamy, Hema Pulidindi
    Journal of Pharmacy and Bioallied Sciences.2024; 16(Suppl 2): S1104.     CrossRef
  • Analysis of the chemical interaction of polyhexanide with endodontic irrigants
    Z. S. Zurab, Yu. A. Generalova, A. A. Kulikova, A. Yu. Umarov, F. V. Badalov, A. Wehbe, E. M. Kakabadze
    Endodontics Today.2024; 22(4): 319.     CrossRef
  • In vitro evaluation of three engineered multispecies endodontic biofilms on a dentinal disk substrate
    Wajih Hage, Dolla Karam Sarkis, Mireille Kallasy, May Mallah, Carla Zogheib
    Biomaterial Investigations in Dentistry.2023;[Epub]     CrossRef
  • In vitro evaluation of enterococcus faecalis growth in different conditions on dentinal substrate
    Wajih Hage, Dolla Karam Sarkis, Mireille Kallassy, May Mallah, Carla Zogheib
    Biomaterial Investigations in Dentistry.2023;[Epub]     CrossRef
  • Bacteria associated with apical periodontitis promotes in vitro the differentiation of macrophages to osteoclasts
    A. P. Torres-Monjarás, R. Sánchez-Gutiérrez, B. Hernández-Castro, L. González-Baranda, D. L. Alvarado-Hernández, A. Pozos-Guillén, A. Muñoz-Ruiz, V. Méndez-González, R. González-Amaro, M. Vitales-Noyola
    Clinical Oral Investigations.2023; 27(6): 3139.     CrossRef
  • Antimicrobial efficacy of Kerr pulp canal sealer (EWT) in combination with 10% amoxicillin on Enterococcus faecalis: A confocal laser scanning microscopic study
    Madhureema De Sarkar, Kundabala Mala, Suchitra Shenoy Mala, Shama Prasada Kabekkodu, Srikant Natarajan, Neeta Shetty, Priyanka Madhav Kamath, Manuel Thomas
    F1000Research.2023; 12: 725.     CrossRef
  • Antimicrobial efficacy of Kerr pulp canal sealer (EWT) in combination with 10% amoxicillin on Enterococcus faecalis: A confocal laser scanning microscopic study
    Madhureema De Sarkar, Kundabala Mala, Suchitra Shenoy Mala, Shama Prasada Kabekkodu, Srikant Natarajan, Neeta Shetty, Priyanka Madhav Kamath, Manuel Thomas
    F1000Research.2023; 12: 725.     CrossRef
  • Combined effect of electrical energy and graphene oxide on Enterococcus faecalis biofilms
    Myung-Jin LEE, Mi-Ah KIM, Kyung-San MIN
    Dental Materials Journal.2023; 42(6): 844.     CrossRef
  • Innovative Curved-Tip Reactor for Non-Thermal Plasma and Plasma-Treated Water Generation: Synergistic Impact Comparison with Sodium Hypochlorite in Dental Root Canal Disinfection
    Raúl Arguello-Sánchez, Régulo López-Callejas, Benjamín Gonzalo Rodríguez-Méndez, Rogelio Scougall-Vilchis, Ulises Velázquez-Enríquez, Antonio Mercado-Cabrera, Rosendo Peña-Eguiluz, Raúl Valencia-Alvarado, Carlo Eduardo Medina-Solís
    Materials.2023; 16(22): 7204.     CrossRef
  • Impact of antimicrobial photodynamic therapy on the bond-strength and penetration of endodontic sealers: A systematic review
    Khalid H Almadi
    Photodiagnosis and Photodynamic Therapy.2023; 41: 103249.     CrossRef
  • Apical periodontitis in mesiobuccal roots of maxillary molars: influence of anatomy and quality of root canal treatment, a CBCT study
    Samantha Jannone Carrion, Marcelo Santos Coelho, Adriana de Jesus Soares, Marcos Frozoni
    Restorative Dentistry & Endodontics.2022;[Epub]     CrossRef
  • Potential relationship between clinical symptoms and the root canal microbiomes of root filled teeth based on the next‐generation sequencing
    Yajing Hou, Liu Wang, Lan Zhang, Xuelian Tan, Dingming Huang, Dongzhe Song
    International Endodontic Journal.2022; 55(1): 18.     CrossRef
  • Efficacy of 6% Sodium Hypochlorite on Infectious Content of Teeth with Symptomatic Irreversible Pulpitis
    Rodrigo Arruda-Vasconcelos, Marlos Barbosa-Ribeiro, Lidiane M. Louzada, Beatriz I.N. Lemos, Adriana de-Jesus-Soares, Caio C.R. Ferraz, José F.A. Almeida, Marina A. Marciano, Brenda P.F. A. Gomes
    Journal of Endodontics.2022; 48(2): 179.     CrossRef
  • Specialized pro-resolving lipid mediators in endodontics: a narrative review
    Davy Aubeux, Ove A. Peters, Sepanta Hosseinpour, Solène Tessier, Valérie Geoffroy, Fabienne Pérez, Alexis Gaudin
    BMC Oral Health.2021;[Epub]     CrossRef
  • Effects of curcumin-mediated antimicrobial photodynamic therapy associated to different chelators against Enterococcus faecalis biofilms
    Daniela Alejandra Cusicanqui Méndez, Maricel Rosario Cardenas Cuéllar, Victor Feliz Pedrinha, Evelyn Giuliana Velásquez Espedilla, Flaviana Bombarda de Andrade, Patrícia de Almeida Rodrigues, Thiago Cruvinel
    Photodiagnosis and Photodynamic Therapy.2021; 35: 102464.     CrossRef
  • Effectiveness of D,L‐2‐hydroxyisocaproic acid (HICA) and alpha‐mangostin against endodontopathogenic microorganisms in a multispecies bacterial–fungal biofilm in anex vivotooth model
    Warat Leelapornpisid, Lilyann Novak‐Frazer, Alison Qualtrough, Riina Rautemaa‐Richardson
    International Endodontic Journal.2021; 54(12): 2243.     CrossRef
  • In Vitro Evaluation of a New Combination of Three Antibiotic Paste Against Common Endodontic Pathogens
    Prasanna Dahake, Nilima Thosar
    Journal of Islamic Dental Association of IRAN.2021; 33(3): 58.     CrossRef
  • Effect of using diode laser on Enterococcus faecalis and its lipoteichoic acid (LTA) in chronic apical periodontitis
    Zhaohui Zou, Junu Bhandari, Baiyan Xiao, Xiaoyue Liang, Yu Zhang, Guohui Yan
    Lasers in Medical Science.2021; 36(5): 1059.     CrossRef
  • Prevalence of Bacteria of Genus Actinomyces in Persistent Extraradicular Lesions—Systematic Review
    Mario Dioguardi, Vito Crincoli, Luigi Laino, Mario Alovisi, Diego Sovereto, Lorenzo Lo Muzio, Giuseppe Troiano
    Journal of Clinical Medicine.2020; 9(2): 457.     CrossRef
  • Evaluation of in vitro biofilm elimination of Enterococcus faecalis using a continuous ultrasonic irrigation device
    Jennifer Galván-Pacheco, Marlen Vitales-Noyola, Ana M. González-Amaro, Heriberto Bujanda-Wong, Antonio Aragón-Piña, Verónica Méndez-González, Amaury Pozos-Guillén
    Journal of Oral Science.2020; 62(4): 415.     CrossRef
  • Comparison of the use of d-enantiomeric and l-enantiomeric antimicrobial peptides incorporated in a calcium-chelating irrigant against Enterococcus faecalis root canal wall biofilms
    Wei-hu Ye, Lara Yeghiasarian, Christopher W. Cutler, Brian E. Bergeron, Stephanie Sidow, Hockin H.K. Xu, Li-na Niu, Jing-zhi Ma, Franklin R. Tay
    Journal of Dentistry.2019; 91: 103231.     CrossRef
  • 1,350 View
  • 49 Download
  • 24 Crossref
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