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  • Research Article
    Association between cigarette smoking and the prevalence of post-endodontic periapical pathology: a systematic review and meta-analysis
    Néstor Ríos-Osorio, Hernan Darío Muñoz-Alvear, Fabio Andrés Jiménez-Castellanos, Sara Quijano-Guauque, Oscar Jiménez-Peña, Herney Andrés García-Perdomo, Javier Caviedes-Bucheli
    Restor Dent Endod 2022;47(3):e27.   Published online June 13, 2022
    DOI: https://doi.org/10.5395/rde.2022.47.e27
    AbstractAbstract PDFPubReaderePub
    Objectives

    This systematic review and meta-analysis aimed to assess the association of cigarette smoking with the prevalence of post-endodontic apical periodontitis in humans.

    Materials and Methods

    We searched through PubMed/Medline, Web of Science, and Scopus from inception to December 2020. Risk of bias was performed by using the Newcastle-Ottawa Scale for cross-sectional, cohort, and case-control studies. We performed the statistical analysis in Review Manager 5.3 (RevMan 5.3).

    Results

    6 studies met the inclusion criteria for qualitative and quantitative synthesis. Statistical analysis of these studies suggests that there were no differences in the prevalence of post endodontic apical periodontitis (AP) when comparing non-smokers vs smoker subjects regarding patients (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.31–1.49; I2 = 58%) and teeth (OR, 1.71; 95% CI, 0.99–2.93; I2 = 72%).

    Conclusions

    Our findings suggest that there was no association between cigarette smoking and post-endodontic apical periodontitis, as we did not find statistical differences in the prevalence of post-endodontic AP when comparing non-smokers vs smoker subjects. Therefore, smoking should not be considered a risk factor associated with endodontic failure.

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