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  • Research Article
    Effect of phytic acid as an endodontic chelator on resin adhesion to sodium hypochlorite-treated dentin
    Mohannad Nassar, Noriko Hiraishi, Md. Sofiqul Islam, Maria JRH. Romero, Masayuki Otsuki, Junji Tagami
    Restor Dent Endod 2020;45(4):e44.   Published online August 24, 2020
    DOI: https://doi.org/10.5395/rde.2020.45.e44
    AbstractAbstract PDFPubReaderePub
    Objectives

    Phytic acid (IP6), a naturally occurring agent, has been previously reported as a potential alternative to ethylenediaminetetraacetic acid (EDTA). However, its effect on adhesion to sodium hypochlorite (NaOCl)-treated dentin and its interactions with NaOCl have not been previously reported. Thus, in this study, the effects of IP6 on resin adhesion to NaOCl-treated dentin and the failure mode were investigated and the interactions between the used agents were analyzed.

    Materials and Methods

    Micro-tensile bond strength (µTBS) testing was performed until failure on dentin treated with either distilled water (control), 5% NaOCl, or 5% NaOCl followed with chelators: 17% EDTA for 1 minute or 1% IP6 for 30 seconds or 1 minute. The failed specimens were assessed under a scanning electron microscope. The reaction of NaOCl with EDTA or IP6 was analyzed in terms of temperature, pH, effervescence, and chlorine odor, and the effects of the resulting mixtures on the color of a stained paper were recorded.

    Results

    The µTBS values of the control and NaOCl with chelator groups were not significantly different, but were all significantly higher than that of the group treated with NaOCl only. In the failure analysis, a distinctive feature was the presence of resin tags in samples conditioned with IP6 after treatment with NaOCl. The reaction of 1% IP6 with 5% NaOCl was less aggressive than the reaction of the latter with 17% EDTA.

    Conclusions

    IP6 reversed the adverse effects of NaOCl on resin-dentin adhesion without the chlorine-depleting effect of EDTA.

    Citations

    Citations to this article as recorded by  
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      Md Sofiqul Islam, Shadi El Bahra, Smriti Aryal A C, Vivek Padmanabhan, Abdulaziz Al Tawil, Ihab Saleh, Muhammed Mustahsen Rahman, Upoma Guha
      Polymers.2025; 17(4): 513.     CrossRef
    • Advancing Adhesive Strategies for Endodontically Treated Teeth—Part I: Impact of Endodontic Irrigation Protocols on the Chemical Composition and Structural Integrity of Coronal Dentin
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      Journal of Esthetic and Restorative Dentistry.2025; 37(7): 1848.     CrossRef
    • Effect of collagen crosslinkers on sodium hypochlorite treated dentin bond strength: a systematic review and meta-analysis
      Weiqing Zhou, Shuting Feng, Xiaojun Chu, Shuaimei Xu, Xiongqun Zeng
      Frontiers in Bioengineering and Biotechnology.2025;[Epub]     CrossRef
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      Journal of Esthetic and Restorative Dentistry.2025; 37(7): 1865.     CrossRef
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      Ecehan Hazar, Ahmet Hazar
      BMC Oral Health.2025;[Epub]     CrossRef
    • Comparative evaluation of free available chlorine in sodium hypochlorite solutions admixed with novel chelating agents
      Somya Tyagi, Sonali Taneja, Kandasamy Nagarajan, Divya Chowdhary
      Endodontology.2025; 37(2): 188.     CrossRef
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      Ummey Salma, C. Pushpalatha, SV. Sowmya, Dominic Augustine, Ahmed Alamoudi, Bassam Zidane, Nassreen Hassan Mohammad Albar, Shilpa Bhandi
      The Saudi Dental Journal.2024; 36(8): 1093.     CrossRef
    • In Vitro Bond Strength of Dentin Treated with Sodium Hypochlorite: Effects of Antioxidant Solutions
      Guillermo Grazioli, Elisa de León Cáceres, Romina Tessore, Rafael Lund, Ana Monjarás-Ávila, Monika Lukomska-Szymanska, Louis Hardan, Rim Bourgi, Carlos Cuevas-Suárez
      Antioxidants.2024; 13(9): 1116.     CrossRef
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      Journal of Conservative Dentistry and Endodontics.2024; 27(2): 186.     CrossRef
    • Effect of phytic acid on dentinal collagen solubilization and its binding and debinding potentials to dentin
      Diletta Forgione, Mohannad Nassar, Roda Seseogullari-Dirihan, Ahmed Jamleh, Arzu Tezvergil-Mutluay
      Journal of Dentistry.2023; 128: 104361.     CrossRef
    • Application of Inositol Hexaphosphate and Inositol in Dental Medicine: An Overview
      Ana Druzijanic, Mare Kovic, Marija Roguljic, Livia Cigic, Martina Majstorovic, Ivana Vucenik
      Biomolecules.2023; 13(6): 913.     CrossRef
    • Ex-vivo study about antimicrobial effectiveness of phytic acid against Enterococcus faecalis into root canals
      Giulia BOSCHI, Giorgio PICCINELLI, Carlo BONFANTI, Stefano A. SALGARELLO
      Minerva Dental and Oral Science.2023;[Epub]     CrossRef
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      Ahmed Mostafa Attia, Ahmed Fawzy Abo-Elezz, Rehab Khalil Safy
      Brazilian Dental Journal.2022; 33(5): 116.     CrossRef
    • Resin-Based Cement Applied to Enamel and Dentin Pre-Treated with Phytic Acid: An In Vitro Study
      Mohannad Nassar, Md. Sofiqul Islam, Smriti Aryal A C, Hatem Mostafa El-Damanhoury, Salvatore Sauro, Noriko Hiraishi
      Applied Sciences.2021; 11(24): 11976.     CrossRef
    • Postspace pretreatment with 17% ethylenediamine tetraacetic acid, 7% maleic acid, and 1% phytic acid on bond strength of fiber posts luted with a self-adhesive resin cement
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      Journal of Conservative Dentistry.2021; 24(6): 558.     CrossRef
    • Phytic Acid: Properties and Potential Applications in Dentistry
      Mohannad Nassar, Rania Nassar, Husain Maki, Abdullah Al-Yagoob, Mahmood Hachim, Abiola Senok, David Williams, Noriko Hiraishi
      Frontiers in Materials.2021;[Epub]     CrossRef
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