Restorative Dentistry & Endodontics

Research Articles

Single-session associative protocol for dentin hypersensitivity management: a 1-year randomized, blinded clinical study: Thayna Carolina Zeni, Poliana Maria de Faveri Cardoso, Rafael da Silva Vanolli, Márcio José Mendonça, Julio Katuhide Ueda, Veridiana Camilotti; Restor Dent Endod 2024;49(2):e15. Published online March 20, 2024; DOI: https://doi.org/10.5395/rde.2024.49.e15

Objectives

This study aimed to establish a single-session associative protocol for non-restorative management of dentin hypersensitivity (DH).

Materials and Methods

Twenty-four individuals with DH and a minimum sensitivity level of 4 on the visual analog scale (VAS) were selected. The study was conducted in a split-mouth design, with each participant (n = 20) having at least 1 affected tooth in all quadrants. The management protocols consisted of control group: universal adhesive, Neural Desensitizing Protocol group: 5% potassium nitrate, Mixed Desensitizing Protocol (PAM) group: 5% sodium fluoride and 5% potassium nitrate, Remineralizing Desensitizing Protocol (PDR) group: surface-partially reacted glass technology photopolymerizable varnish. Evaluations were performed immediately after application, at 1 week, 1 month, 2 months, and 12 months using the VAS sensitivity test.

Results

The scores were subjected to statistical analysis using the Friedman test (p < 0.05), Durbin-Conover test (p < 0.05), and Wilcoxon test (p < 0.05). At the 12-month evaluation, all groups showed statistically significant differences compared to the initial assessment. For the evaluation after 12 months, there was a statistically significant difference between the PAM group, the control group, and the PDR group.

Conclusions

It can be concluded that all groups were effective in controlling DH, but there were significant results in the control group and PDR group. The clinical relevance of this study is to demonstrate that the application of single-session desensitizing protocols can be effective in controlling DH for up to 12 months.

Trial Registration

Brazilian Clinical Trials Registry Identifier: RBR-4r63d7s

Citations

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In vivo and in situ evaluation of innovative approaches in dentin hypersensitivity treatment
Heba Abd El-Fattah Mohamed, Dina Ezzeldin Mohamed, Elhassan Hassanein, Heba El-din Salah El-din Hamza
BMC Oral Health.2025;[Epub] CrossRef
Desensitizing efficacy of a universal dentin adhesive containing mesoporous bioactive glass on dentin hypersensitivity: a randomized clinical trial with a split-mouth model
Hyun-Jung Kim, Soram Oh, Jiyoung Kwon, Kyoung-Kyu Choi, Ji-Hyun Jang, Duck-Su Kim
Scientific Reports.2024;[Epub] CrossRef

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Influence of pain-relieving therapies on inflammation and the expression of proinflammatory neuropeptides after dental bleaching treatment: Livia Maria Alves Valentim da Silva, Luciano Tavares Angelo Cintra, Marjorie de Oliveira Gallinari, Francine Benetti, Vanessa Rahal, Edilson Ervolino, Sibele de Alcântara, André Luiz Fraga Briso; Restor Dent Endod 2020;45(2):e20. Published online February 28, 2020; DOI: https://doi.org/10.5395/rde.2020.45.e20

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Objectives

To minimize the tooth sensitivity caused by in-office bleaching, many dentists use non-steroidal anti-inflammatory drugs and topical desensitizing gels containing potassium nitrate and sodium fluoride. This study aimed to evaluate the influence of these substances on inflammation and the expression of substance P and calcitonin gene-related peptide in pulp nerve fibers.

Materials and Methods

Seventy-two rats were divided into 6 groups as follows: GI, control; GII, only dental bleaching; GIII, only ibuprofen; GIV, ibuprofen administered 30 minutes before and after the bleaching treatment and every 12 hours until the analysis; GV, only topical application of a desensitizing agent; and GVI, topical application of a desensitizing agent before dental bleaching. Placebo gel was applied to the upper left jaw and the bleaching agent was applied to the upper right jaw in all groups. Subsequently, the groups were divided into 3 subgroups based on the time of analysis: 0, 24, and 48 hours after bleaching (n = 8). The rats were euthanized and the maxillae were processed and evaluated by histopathological and immunohistochemical analyses. The data were analyzed using the Kruskal-Wallis test, followed by the Dunn test (p < 0.05).

Results

In the bleaching groups, the inflammatory process and expression of neuropeptides decreased over time. The animals in which a desensitizing agent was applied showed better results within 24 hours.

Conclusions

The use of a desensitizing agent had positive effects on inflammation and pain-related neuropeptide expression, minimizing the painful effects of dental bleaching treatment.

Citations

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Effectiveness of Analgesics in Dental Whitening Pain Management: A Systematic Review and Meta-Analysis
Gabriella Alves Julião Costa, Caio Ferreira Freire Caetano, Ravy Jucá Farias, Diana Araújo Cunha, Dayrine Silveira de Paula, Edson Luiz Cetira Filho, Paulo Goberlânio de Barros Silva
Expert Opinion on Pharmacotherapy.2025; 26(5): 639. CrossRef
Influence of dental bleaching on the pulp tissue: A systematic review of in vivo studies
Mariana Viana Donato, Alexandre Henrique dos Reis‐Prado, Lucas Guimarães Abreu, Lara Cancella de Arantes, Juliana Goto, Hebertt Gonzaga dos Santos Chaves, Luciano Tavares Angelo Cintra, André Luiz Fraga Briso, Isabella Faria da Cunha Peixoto, Francine Ben
International Endodontic Journal.2024; 57(6): 630. CrossRef
Role of induced nitric oxide synthases in orofacial nociception/discomfort after dental tooth bleaching with hydrogen peroxide
Marcílio Rodrigues Pinto, Kirlya Isabel da Silva Medeiros, Letícia Menezes Maia, Antonio Alexandre Coelho, Ana Paula Negreiros Nunes Alves, Caio Ferreira Freire Caetano, Karine Cestaro Mesquita, Paulo Goberlânio de Barros Silva, Fabricio Bitu Sousa
Archives of Oral Biology.2024; 161: 105937. CrossRef
Can different agents reduce the damage caused by bleaching gel to pulp tissue? A systematic review of basic research
Letícia Aparecida Silva Batista, Alexandre Henrique dos Reis-Prado, Hebertt Gonzaga dos Santos Chaves, Lara Cancella de Arantes, Luís Fernando Santos Alves Morgan, Carolina Bosso André, Thaís Yumi Suzuki, Francine Benetti
Restorative Dentistry & Endodontics.2023;[Epub] CrossRef
The Effects of Different Drugs with Anti-Inflamatory Potential in Prevention of Pulp Damage During the Teeth Bleaching
Miona Glisic, Andjela Milojevic, Milica Milinkovic, Marina Rankovic
Experimental and Applied Biomedical Research (EABR).2023;[Epub] CrossRef
Bleaching gel volume influences hydrogen peroxide diffusion, inflammation, and the presence of nitric oxide in the pulp tissue: in vitro and in vivo model
Sibele de ALCÂNTARA, Francine BENETTI, Lívia Maria Alves Valentim da SILVA, Nathália Evelyn da Silva MACHADO, Isabela Joane Prado SILVA, Lara Maria Bueno ESTEVES, Edilson ERVOLINO, Luciano Tavares Angelo CINTRA, André Luiz Fraga BRISO
Journal of Applied Oral Science.2023;[Epub] CrossRef
Design of a thermosensitive ibuprofen-loaded nanogel as smart material applied as anti-inflammatory in tooth bleaching: An in vivo study
Samara K.S.C.F. Moura, Milena L.V. dos Santos, Lucas A. do Nascimento, Mariana F.A. da Silva, Glória M. de França, Lucas M. da Costa, Aldo C. Medeiros, Raimundo F. Araújo-Júnior, Aurigena A. de Araújo, Cláudia N. Oliveira, André L. Dorini, Rejane A. de Ca
Journal of Drug Delivery Science and Technology.2022; 68: 103123. CrossRef
Topical application of Otosporin® before in-office bleaching: a split mouth, triple-blind, multicenter randomized clinical trial
Michael Willian Favoreto, Laína Vochikovski, Renata Maria Oleniki Terra, Veridiana Silva Campos, Mariana Evangelista Santos, Sônia Saeger Meireles, Alessandra Reis, Alessandro D. Loguercio
Clinical Oral Investigations.2022; 26(3): 2555. CrossRef
A novel tooth bleaching gel based on peroxymonosulfate/polyphosphates advanced oxidation process: Effective whitening avoiding pulp damage and sensitivity
Su Yang, Baiyan Sui, Xin Liu, Jiao Sun, Jun Wang
Chemical Engineering Journal.2022; 429: 132525. CrossRef
Effectiveness of Violet LED alone or in association with bleaching gel during dental photobleaching: A Systematic Review
Bianca Rossi, Susana Morimoto, Tamara Kerber Tedesco, Sandra Ribeiro Cunha, Anna Carolina Ratto Tempestini Horliana, Karen Müller Ramalho
Photodiagnosis and Photodynamic Therapy.2022; 38: 102813. CrossRef

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Publication patterns in Restorative Dentistry and Endodontics: Sherin Jose Chockattu, Byathnal Suryakant Deepak; Restor Dent Endod 2019;44(3):e34. Published online August 8, 2019; DOI: https://doi.org/10.5395/rde.2019.44.e34

Abstract PDF PubReader ePub

Objectives

Restorative Dentistry and Endodontics (Restor Dent Endod; RDE) is an English-language journal published by the Korean Academy of Conservative Dentistry, and it has been online since 2012 with quarterly publications. The purpose of this paper was to review and analyze the publications in this journal since its inception and over the 7-year period from 2012 to 2018.

Materials and Methods

This paper assessed the number, type, and subject of articles published, as well as authorship patterns and article citations of the journal over a 7-year period. The citation indicator for the journal (h-index) was assessed using Google Scholar.

Results

The number of articles per issue has remained relatively consistent in the 7 years that were analyzed. An analysis of the article types revealed various categories of review articles. Original research articles accounted for the most articles per volume. Twice as many articles per volume were on endodontic topics than on restorative subjects. Articles published in RDE have been widely cited in Synapse, Crossref, and PubMed Central. A country-wise mapping of authors' institutions revealed significant contributions from authors around the world. With an h-index of 24, RDE ranks third among journals in its specialty. The most cited articles were open lectures on statistics and research articles on recent concepts, technology, and materials.

Conclusion

Over the last 7 years, RDE has served as a platform for a large number of manuscripts in the field of restorative dentistry and endodontics.

Citations

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The trend of publications in the Journal of Conservative Dentistry and Endodontics: A 6-year systematic survey of the journal
Muhammad Hamdan, Ganesh Ranganath Jadhav, Prerna Verma
Journal of Conservative Dentistry and Endodontics.2025; 28(2): 126. CrossRef
Effects of Photobiomodulation on Oral Mucositis: Visualization and Analysis of Knowledge
Wallacy Watson Pereira Melo, Walessa Alana Bragança Aragão, Daiane Claydes Baia-da-Silva, Priscila Cunha Nascimento, Rafael Rodrigues Lima, Renata Duarte de Souza-Rodrigues
Life.2022; 12(11): 1940. CrossRef

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