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  • Original Article
    The effect of Treponema denticola immunoinhibitory protein on cytokine expression in T cells
    Sang-Yup Lee, Won-Jun Shon, WooCheol Lee, Seung-Ho Baek, Kwang-Shik Bae, SungSam Lim
    J Korean Acad Conserv Dent 2004;29(5):479-484.   Published online September 30, 2004
    DOI: https://doi.org/10.5395/JKACD.2004.29.5.479
    AbstractAbstract PDFPubReaderePub

    Immunoinhibitory protein extracted from sonicated Treponema denticola have been shown to suppress cell cycle progression of human lymphocytes. To study in detail about the effect of this microorganism on the function of lymphocytes, we investigated the levels of Interleukin-2 (IL-2) and Interleukin-4 (IL-4) production by T lymphocytes before and after the addition of 12.5 µg/ml T. denticola sonicated extracts. In this study, levels of IL-2 and IL-4 produced from T cells pretreated with sonicated extracts were evaluated by using the quantitative sandwich enzyme immunoassay technique. In response to phytohemagglutinin (PHA) stimulation, T cell produced increased levels of IL-2 and IL-4. However, the expressions of both cytokines were significantly inhibited when PHA activated-T cells were pre-exposed to sonicated T. denticola extracts (p < 0.05). These findings suggest that the T. denticola sonicated extracts induced-immunosuppression in Th1 and Th2 cell functions could be a part of the pathogenic mechanism of the endodontic failure associated with this microorganism.

    Citations

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    • TLR5 activation induces expression of the pro‐inflammatory mediator Urokinase Plasminogen Activator via NF‐κB and MAPK signalling pathways in human dental pulp cells
      H.‐S. Hwang, J.‐W. Kim, S.‐H. Oh, J. H. Song, J.‐W. Yang, Y. Zang, Y.‐H. Kim, S.‐E. Lee, Y.‐C. Hwang, J.‐T. Koh
      International Endodontic Journal.2019; 52(10): 1479.     CrossRef
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