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HOME > Restor Dent Endod > Volume 30(5); 2005 > Article
Original Article Expression of OD314 during ameloblast differentiation and maturation
Joo-Cheol Park1, Seong-Min Ahn1, Heung-Joong Kim1, Moon-Jin Jeong1, Min-Ju Park1, In-Cheol Shin1, Ho-Hyun Son2
2005;30(5):-431.
DOI: https://doi.org/10.5395/JKACD.2005.30.5.423
Published online: September 30, 2005

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Corresponding author: Ho-Hyun Son. Department of Conservative Dentistry, School of Dentistry, Seoul National University, 28 Yongon-dong, Chongno-gu, Seoul, Korea 110-749. Tel: 82-2-2072-2652, Fax: 82-2-2072-3859, hhson@snu.ac.kr
• Received: May 13, 2005   • Revised: July 28, 2005   • Accepted: August 23, 2005

Copyright © 2005 Korean Academy of Conservative Dentistry

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  • Ameloblasts are responsible for the formation and maintenance of enamel which is an epithelially derived protective covering for teeth. Ameloblast differentiation is controlled by sequential epithelial-mesenchymal interactions. However, little is known about the differentiation and maturation mechanisms. OD314 was firstly identified from odontoblasts by subtraction between odontoblast/pulp cells and osteoblast/dental papilla cells, even though OD314 protein was also expressed in ameloblast during tooth formation.
    In this study, to better understand the biological function of OD314 during amelogenesis, we examined expression of the OD314 mRNA and protein in various stages of ameloblast differentiation using in-situ hybridization and immunohistochemistry.
    The results were as follows :
    1. The ameloblast showed 4 main morphological and functional stages referred to as the presecretory, secretory, smooth-ended, and ruffle-ended.
    2. OD314 mRNA was expressed in secretory ameloblast and increased according to the maturation of the cells.
    3. OD314 protein was not expressed in presecretory ameloblast but expressed in secretory ameloblast and maturative ameloblast. OD314 protein was distributed in entire cytoplasm of secretory ameloblast. However, OD314 was localized at the proxiamal and distal portion of the cytoplasm of smooth-ended and ruffle-ended ameloblast.
    These results suggest that OD314 may play important roles in the ameloblast differentiation and maturation.
  • Keywords: Ameloblast; OD314; Differentiation; Maturation; Smooth-ended; Ruffle-ended
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Figure 1
The various functional stages of the ameloblast. Panel A, Ameloblast of presecretory stage; panel B, Ameloblast of secretory stage; panel C, Smooth-ended ameloblast of maturative stage; panel D, Ruffle-ended ameloblast of maturative stage.
jkacd-30-423-g001.jpg
Figure 2
Mandibular incisor of 3-week-old mouse hybridized with antisense cRNA probes of OD314. Panel A, Low magnification micrograph showing OD314 mRNA expression; panel B, High power view of zone I in panel A; panel C, High power view of zone II in panel A; panel D, High power view of zone III in panel A.
jkacd-30-423-g002.jpg
Figure 3
Immunohistochemical localization of OD314 in the various functional stages of ameloblast. Panel A, Ameloblast of presecretory stage; panel B, Ameloblast of secretory stage; panel C, Smooth-ended ameloblast of maturative stage; panel D, Ruffle-ended ameloblast of maturative stage.
jkacd-30-423-g003.jpg

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        Expression of OD314 during ameloblast differentiation and maturation
        J Korean Acad Conserv Dent. 2005;30(5):423-431.   Published online September 30, 2005
        DOI: https://doi.org/10.5395/JKACD.2005.30.5.423
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      Expression of OD314 during ameloblast differentiation and maturation
      Image Image Image
      Figure 1 The various functional stages of the ameloblast. Panel A, Ameloblast of presecretory stage; panel B, Ameloblast of secretory stage; panel C, Smooth-ended ameloblast of maturative stage; panel D, Ruffle-ended ameloblast of maturative stage.
      Figure 2 Mandibular incisor of 3-week-old mouse hybridized with antisense cRNA probes of OD314. Panel A, Low magnification micrograph showing OD314 mRNA expression; panel B, High power view of zone I in panel A; panel C, High power view of zone II in panel A; panel D, High power view of zone III in panel A.
      Figure 3 Immunohistochemical localization of OD314 in the various functional stages of ameloblast. Panel A, Ameloblast of presecretory stage; panel B, Ameloblast of secretory stage; panel C, Smooth-ended ameloblast of maturative stage; panel D, Ruffle-ended ameloblast of maturative stage.

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      Figure 3

      Expression of OD314 during ameloblast differentiation and maturation
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