Department of Endodontics, School of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
Copyright © 2019. The Korean Academy of Conservative Dentistry
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
First author (yr) | Study design | Type of trauma | Intracanal material (No. of teeth) | Replantation time | Details of the procedure | Main result |
---|---|---|---|---|---|---|
Panzarini et al. [29] (2007) | Animal study on monkeys | Avulsion | CH (6) | Immediate replantation | - Storage: in saline solution for 15 min | - Ankylosis: NS |
MTA (6) | - Surface treatment: none | - IRR: NS | ||||
- Splinting: 14 days | ||||||
- Sacrifice: 180 days | ||||||
- ABA: single dose of benzathine penicillin 320,000 IU | ||||||
Panzarini et al. [32] (2014) | Animal study on monkeys | Avulsion | CH (10) | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: significantly lower in MTA group (p = 0.04) |
MTA (10) | - Surface treatment: 10 min in 2% acidulated phosphate sodium fluoride | - IRR: NS | ||||
- Splinting: 30 days | ||||||
- Sacrifice: 60 days | ||||||
- ABA: penicillin V (250 mg; 3 drops/day for 7 days) | ||||||
Marão et al. [33] (2012) | Animal study on Wistar rats | Avulsion | CH (10) | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: NS |
MTA (10) | - Surface treatment: 10 min in 2% acidulated phosphate sodium fluoride | - IRR: NS | ||||
- Splinting: not mentioned | ||||||
- Sacrifice: 80 days | ||||||
- ABA: single IM dose of benzathine G penicillin 20,000 IU | ||||||
Esteves et al. [34] (2015) | Animal study on Wistar rats | Avulsion | Control (8) | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: NS |
CH (9) | - Surface treatment: 10 min in 2% acidulated phosphate sodium fluoride | - IRR: significantly lower in MTA group (p = 0.0006) | ||||
MTA plug & CH filling (10) | - Splinting: not mentioned | |||||
- Sacrifice: 60 days | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Vogt et al. [31] (2016) | Animal study on Wistar rats | Avulsion | Control (12) | Delayed replantation | - Storage: 30 min bench-dried | - At 10 days: NS regarding IRR |
CH (12) | - Surface treatment: 30 min in 1% sodium hypochlorite and 20 min in 2% sodium fluoride solution | - At 60 days: only ankylosis extension showed a statistically significant difference between the MTA Fillapex and the control (p < 0.05) | ||||
MTA (12) | - Splinting: none | |||||
MTA Fillapex (12) | - Sacrifice: 10 and 60 days | |||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Ferreira et al. [35] (2017) | Animal study on Wistar rats | Avulsion | CH | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: NS |
MTA Fillapex | - Surface treatment: 10 min in 2.72% acidulated phosphate sodium fluoride | - IRR: NS | ||||
- Splinting: performed by silk 3/0 but the duration was not mentioned | ||||||
- Sacrifice: 8 weeks | ||||||
- ABA: not mentioned | ||||||
Negri et al. [17] (2008) | Animal study on Wistar rats | Avulsion | CH-based paste* (8) | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: NS |
Sealapex (8) | - Surface treatment: 10 min in 2% acidulated phosphate sodium fluoride | - IRR: NS | ||||
Endofill (8) | - Splinting: none | |||||
- Sacrifice: 60 days | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Day et al. [36] (2012) | Multicenter randomized controlled trial | Avulsion | CH (15 teeth/12 patients) | Delayed or immediate replantation | - Storage: a maximum of 20 min dry extra-alveolar storage time, or the aforementioned scenario plus a maximum of 60 min extra-alveolar time, kept in milk or another appropriate storage media | - Ankylosis: NS |
Ledermix (12 teeth/10 patients) | - RCT procedure: pulp extirpated and dressed with CH or Ledermix within 7–10 days, at days 60–90 re-dressed with CH, at month 6 obturated if no sign of active resorption, at year 1 definite diagnosis or patient continued to be reviewed until healing | - Periodontal healing: NS | ||||
- Splinting: 7–10 days | ||||||
- Clinical visits: 60–90 days, 6 months ± 14 days, 1 year ± 14 days | ||||||
- ABA: amoxicillin, if allergic another suitable antibiotic | ||||||
Thong et al. [37] (2001) | Animal study on monkeys | Avulsion | Control (12) | Immediate replantation | - Storage: 15 min bench-dried | - Ankylosis: significantly lower in Ledermix group than in CH group (p < 0.05), but NS when the untreated control was compared with either treatment group |
CH (11) | - Surface treatment: none | - IRR: NS between CH and Ledermix, but significantly lower in both treatment groups than in the control group (p < 0.05) | ||||
Ledermix (12) | - Splinting: none | |||||
- Sacrifice: after 8 weeks | ||||||
- ABA: not mentioned | ||||||
Bryson et al. [38] (2002) | Animal study on mongrel dogs | Avulsion | CH (15) | Delayed replantation | - Storage: 60 min bench-dried | - Favorable healing (presence of cementum over the dentin surface whether previously resorbed or not), and poor healing (including IRR or ankylosis): Ledermix exhibited a significantly greater amount of favorable healing (p = 0.004) |
Ledermix (14) | - Surface treatment: not mentioned | |||||
- Splinting: none | ||||||
- Sacrifice: 4 months | ||||||
- ABA: not mentioned | ||||||
Mori et al. [43] (2007) | Animal study on Wistar rats | Avulsion | CH (15) | Delayed replantation | - Storage: 30 min bench-dried | - At 15 days: NS |
Alendronate (15) | - Surface treatment: 30 min in 1% hypochlorite solution and 20 min in 2% acidulated phosphate sodium fluoride | - At 30 days: IRR, RRR, and ankylosis were greater in the CH group (p < 0.05) | ||||
- Splinting: none | - At 60 days: NS | |||||
- Sacrifice: 15, 30, and 60 days | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Thong et al. [7] (2009) | Animal study on monkeys | Avulsion | Control (plaque) (5) | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: was the least in the control and the greatest in the bisphosphonate-treated group (p < 0.05); the difference was NS between the CH and bisphosphonate groups, but both had significantly higher ankylosis occurrence than the untreated control (p = 0.01) |
CH (7) | - Surface treatment: | - IRR: was significantly greater in the control than in the 2 treatment groups (p = 0.02), but was NS between the CH and bisphosphonate groups | ||||
Bisphosphonate (etidronate disodium) (11) | - Splinting: none | |||||
- Sacrifice: 8 weeks | ||||||
- ABA: not mentioned | ||||||
Mori et al. [45] (2006) | Animal study on Wistar rats | Avulsion | CH | Delayed replantation | - Storage: 30 min bench-dried | - At 15 days: NS |
Acetazolamide solution | - Surface treatment: 30 min in 1% hypochlorite solution and 20 min in 2% acidulated phosphate sodium fluoride | - At 30 days: ankylosis and RRR were greater in the CH group (p < 0.05) | ||||
- Sacrifice: 15, 30, and 60 days | - At 60 days: RRR and IRR were greater in the CH group (p < 0.05) | |||||
- Splinting: none | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Mori et al. [46] (2013) | Animal study on Wistar rats | Avulsion | CH | Delayed replantation | - Storage: 30 min bench-dried | - Ankylosis: NS |
Acetazolamide paste | - Surface treatment: 20 min in 1% hypochlorite solution and 20 min in 2% acidulated phosphate sodium fluoride | - RRR: at 60 days, was greater in the CH group (p < 0.05) | ||||
- Splinting: none | - IRR: NS | |||||
- Sacrifice: at 15 and 60 days | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Zanetta-Barbosa et al. [50] (2014) | Animal study on dogs | Avulsion | Control (6) | Delayed replantation | - Storage: 50 min bench-dried | - Ankylosis: NS |
CH (6) | - Surface treatment: 10 min in 0.9% physiologic saline, or CH solution (50 mg/mL), or indomethacin solution (50 mg/mL), or CH + indomethacin solution (25 mg/mL of each) | - IRR: NS | ||||
Indomethacin (6) | - Splinting 15 days | |||||
CH + indomethacin (6) | - Sacrifice: on day 120 | |||||
- ABA: single dose of penicillin G procaine 300,000 IU and sodium penicillin G 100,000 IU | ||||||
Mori et al. [56] (2006) | Animal study on Wistar rats | Avulsion | CH | Delayed replantation | - Storage: 30 min bench-dried | - At 15 days: NS |
Gallium nitrate | - Surface treatment: 30 min in 1% hypochlorite solution and 20 min in 2% acidulated phosphate sodium fluoride | - At 30 days: ankylosis and RRR were greater in the CH group (p < 0.05) | ||||
- Splinting: none | - At 60 days: NS | |||||
- Sacrifice: at 15, 30, and 60 days | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
de Oliveira et al. [59] (2013) | Animal study on Wistar rats | Avulsion | CH (8) | Delayed replantation | - Storage/surface treatment: 45 min in saturated solution of sodium chloride | - Emdogain-treated teeth showed a lower percentage of surface resorption (31.58%) than the CH group (80.48%) (p = 0.0006) |
Enamel Matrix-derived protein (Emdogain) (8) | - Splinting: not mentioned | |||||
- Sacrifice: 25 days | ||||||
- ABA: none |
Conflict of Interest: No potential conflict of interest relevant to this article was reported.
Author Contributions:
First author (yr) | Study design | Type of trauma | Intracanal material (No. of teeth) | Replantation time | Details of the procedure | Main result |
---|---|---|---|---|---|---|
Panzarini et al. [29] (2007) | Animal study on monkeys | Avulsion | CH (6) | Immediate replantation | - Storage: in saline solution for 15 min | - Ankylosis: NS |
MTA (6) | - Surface treatment: none | - IRR: NS | ||||
- Splinting: 14 days | ||||||
- Sacrifice: 180 days | ||||||
- ABA: single dose of benzathine penicillin 320,000 IU | ||||||
Panzarini et al. [32] (2014) | Animal study on monkeys | Avulsion | CH (10) | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: significantly lower in MTA group (p = 0.04) |
MTA (10) | - Surface treatment: 10 min in 2% acidulated phosphate sodium fluoride | - IRR: NS | ||||
- Splinting: 30 days | ||||||
- Sacrifice: 60 days | ||||||
- ABA: penicillin V (250 mg; 3 drops/day for 7 days) | ||||||
Marão et al. [33] (2012) | Animal study on Wistar rats | Avulsion | CH (10) | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: NS |
MTA (10) | - Surface treatment: 10 min in 2% acidulated phosphate sodium fluoride | - IRR: NS | ||||
- Splinting: not mentioned | ||||||
- Sacrifice: 80 days | ||||||
- ABA: single IM dose of benzathine G penicillin 20,000 IU | ||||||
Esteves et al. [34] (2015) | Animal study on Wistar rats | Avulsion | Control (8) | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: NS |
CH (9) | - Surface treatment: 10 min in 2% acidulated phosphate sodium fluoride | - IRR: significantly lower in MTA group (p = 0.0006) | ||||
MTA plug & CH filling (10) | - Splinting: not mentioned | |||||
- Sacrifice: 60 days | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Vogt et al. [31] (2016) | Animal study on Wistar rats | Avulsion | Control (12) | Delayed replantation | - Storage: 30 min bench-dried | - At 10 days: NS regarding IRR |
CH (12) | - Surface treatment: 30 min in 1% sodium hypochlorite and 20 min in 2% sodium fluoride solution | - At 60 days: only ankylosis extension showed a statistically significant difference between the MTA Fillapex and the control (p < 0.05) | ||||
MTA (12) | - Splinting: none | |||||
MTA Fillapex (12) | - Sacrifice: 10 and 60 days | |||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Ferreira et al. [35] (2017) | Animal study on Wistar rats | Avulsion | CH | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: NS |
MTA Fillapex | - Surface treatment: 10 min in 2.72% acidulated phosphate sodium fluoride | - IRR: NS | ||||
- Splinting: performed by silk 3/0 but the duration was not mentioned | ||||||
- Sacrifice: 8 weeks | ||||||
- ABA: not mentioned | ||||||
Negri et al. [17] (2008) | Animal study on Wistar rats | Avulsion | CH-based paste* (8) | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: NS |
Sealapex (8) | - Surface treatment: 10 min in 2% acidulated phosphate sodium fluoride | - IRR: NS | ||||
Endofill (8) | - Splinting: none | |||||
- Sacrifice: 60 days | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Day et al. [36] (2012) | Multicenter randomized controlled trial | Avulsion | CH (15 teeth/12 patients) | Delayed or immediate replantation | - Storage: a maximum of 20 min dry extra-alveolar storage time, or the aforementioned scenario plus a maximum of 60 min extra-alveolar time, kept in milk or another appropriate storage media | - Ankylosis: NS |
Ledermix (12 teeth/10 patients) | - RCT procedure: pulp extirpated and dressed with CH or Ledermix within 7–10 days, at days 60–90 re-dressed with CH, at month 6 obturated if no sign of active resorption, at year 1 definite diagnosis or patient continued to be reviewed until healing | - Periodontal healing: NS | ||||
- Splinting: 7–10 days | ||||||
- Clinical visits: 60–90 days, 6 months ± 14 days, 1 year ± 14 days | ||||||
- ABA: amoxicillin, if allergic another suitable antibiotic | ||||||
Thong et al. [37] (2001) | Animal study on monkeys | Avulsion | Control (12) | Immediate replantation | - Storage: 15 min bench-dried | - Ankylosis: significantly lower in Ledermix group than in CH group (p < 0.05), but NS when the untreated control was compared with either treatment group |
CH (11) | - Surface treatment: none | - IRR: NS between CH and Ledermix, but significantly lower in both treatment groups than in the control group (p < 0.05) | ||||
Ledermix (12) | - Splinting: none | |||||
- Sacrifice: after 8 weeks | ||||||
- ABA: not mentioned | ||||||
Bryson et al. [38] (2002) | Animal study on mongrel dogs | Avulsion | CH (15) | Delayed replantation | - Storage: 60 min bench-dried | - Favorable healing (presence of cementum over the dentin surface whether previously resorbed or not), and poor healing (including IRR or ankylosis): Ledermix exhibited a significantly greater amount of favorable healing (p = 0.004) |
Ledermix (14) | - Surface treatment: not mentioned | |||||
- Splinting: none | ||||||
- Sacrifice: 4 months | ||||||
- ABA: not mentioned | ||||||
Mori et al. [43] (2007) | Animal study on Wistar rats | Avulsion | CH (15) | Delayed replantation | - Storage: 30 min bench-dried | - At 15 days: NS |
Alendronate (15) | - Surface treatment: 30 min in 1% hypochlorite solution and 20 min in 2% acidulated phosphate sodium fluoride | - At 30 days: IRR, RRR, and ankylosis were greater in the CH group (p < 0.05) | ||||
- Splinting: none | - At 60 days: NS | |||||
- Sacrifice: 15, 30, and 60 days | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Thong et al. [7] (2009) | Animal study on monkeys | Avulsion | Control (plaque) (5) | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: was the least in the control and the greatest in the bisphosphonate-treated group (p < 0.05); the difference was NS between the CH and bisphosphonate groups, but both had significantly higher ankylosis occurrence than the untreated control (p = 0.01) |
CH (7) | - Surface treatment: | - IRR: was significantly greater in the control than in the 2 treatment groups (p = 0.02), but was NS between the CH and bisphosphonate groups | ||||
Bisphosphonate (etidronate disodium) (11) | - Splinting: none | |||||
- Sacrifice: 8 weeks | ||||||
- ABA: not mentioned | ||||||
Mori et al. [45] (2006) | Animal study on Wistar rats | Avulsion | CH | Delayed replantation | - Storage: 30 min bench-dried | - At 15 days: NS |
Acetazolamide solution | - Surface treatment: 30 min in 1% hypochlorite solution and 20 min in 2% acidulated phosphate sodium fluoride | - At 30 days: ankylosis and RRR were greater in the CH group (p < 0.05) | ||||
- Sacrifice: 15, 30, and 60 days | - At 60 days: RRR and IRR were greater in the CH group (p < 0.05) | |||||
- Splinting: none | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Mori et al. [46] (2013) | Animal study on Wistar rats | Avulsion | CH | Delayed replantation | - Storage: 30 min bench-dried | - Ankylosis: NS |
Acetazolamide paste | - Surface treatment: 20 min in 1% hypochlorite solution and 20 min in 2% acidulated phosphate sodium fluoride | - RRR: at 60 days, was greater in the CH group (p < 0.05) | ||||
- Splinting: none | - IRR: NS | |||||
- Sacrifice: at 15 and 60 days | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Zanetta-Barbosa et al. [50] (2014) | Animal study on dogs | Avulsion | Control (6) | Delayed replantation | - Storage: 50 min bench-dried | - Ankylosis: NS |
CH (6) | - Surface treatment: 10 min in 0.9% physiologic saline, or CH solution (50 mg/mL), or indomethacin solution (50 mg/mL), or CH + indomethacin solution (25 mg/mL of each) | - IRR: NS | ||||
Indomethacin (6) | - Splinting 15 days | |||||
CH + indomethacin (6) | - Sacrifice: on day 120 | |||||
- ABA: single dose of penicillin G procaine 300,000 IU and sodium penicillin G 100,000 IU | ||||||
Mori et al. [56] (2006) | Animal study on Wistar rats | Avulsion | CH | Delayed replantation | - Storage: 30 min bench-dried | - At 15 days: NS |
Gallium nitrate | - Surface treatment: 30 min in 1% hypochlorite solution and 20 min in 2% acidulated phosphate sodium fluoride | - At 30 days: ankylosis and RRR were greater in the CH group (p < 0.05) | ||||
- Splinting: none | - At 60 days: NS | |||||
- Sacrifice: at 15, 30, and 60 days | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
de Oliveira et al. [59] (2013) | Animal study on Wistar rats | Avulsion | CH (8) | Delayed replantation | - Storage/surface treatment: 45 min in saturated solution of sodium chloride | - Emdogain-treated teeth showed a lower percentage of surface resorption (31.58%) than the CH group (80.48%) (p = 0.0006) |
Enamel Matrix-derived protein (Emdogain) (8) | - Splinting: not mentioned | |||||
- Sacrifice: 25 days | ||||||
- ABA: none |
First author (yr) | Study design | Type of trauma | Intracanal material (No. of teeth) | Replantation time | Details of the procedure | Main result |
---|---|---|---|---|---|---|
Panzarini et al. [ | Animal study on monkeys | Avulsion | CH (6) | Immediate replantation | - Storage: in saline solution for 15 min | - Ankylosis: NS |
MTA (6) | - Surface treatment: none | - IRR: NS | ||||
- Splinting: 14 days | ||||||
- Sacrifice: 180 days | ||||||
- ABA: single dose of benzathine penicillin 320,000 IU | ||||||
Panzarini et al. [ | Animal study on monkeys | Avulsion | CH (10) | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: significantly lower in MTA group (p = 0.04) |
MTA (10) | - Surface treatment: 10 min in 2% acidulated phosphate sodium fluoride | - IRR: NS | ||||
- Splinting: 30 days | ||||||
- Sacrifice: 60 days | ||||||
- ABA: penicillin V (250 mg; 3 drops/day for 7 days) | ||||||
Marão et al. [ | Animal study on Wistar rats | Avulsion | CH (10) | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: NS |
MTA (10) | - Surface treatment: 10 min in 2% acidulated phosphate sodium fluoride | - IRR: NS | ||||
- Splinting: not mentioned | ||||||
- Sacrifice: 80 days | ||||||
- ABA: single IM dose of benzathine G penicillin 20,000 IU | ||||||
Esteves et al. [ | Animal study on Wistar rats | Avulsion | Control (8) | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: NS |
CH (9) | - Surface treatment: 10 min in 2% acidulated phosphate sodium fluoride | - IRR: significantly lower in MTA group (p = 0.0006) | ||||
MTA plug & CH filling (10) | - Splinting: not mentioned | |||||
- Sacrifice: 60 days | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Vogt et al. [ | Animal study on Wistar rats | Avulsion | Control (12) | Delayed replantation | - Storage: 30 min bench-dried | - At 10 days: NS regarding IRR |
CH (12) | - Surface treatment: 30 min in 1% sodium hypochlorite and 20 min in 2% sodium fluoride solution | - At 60 days: only ankylosis extension showed a statistically significant difference between the MTA Fillapex and the control (p < 0.05) | ||||
MTA (12) | - Splinting: none | |||||
MTA Fillapex (12) | - Sacrifice: 10 and 60 days | |||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Ferreira et al. [ | Animal study on Wistar rats | Avulsion | CH | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: NS |
MTA Fillapex | - Surface treatment: 10 min in 2.72% acidulated phosphate sodium fluoride | - IRR: NS | ||||
- Splinting: performed by silk 3/0 but the duration was not mentioned | ||||||
- Sacrifice: 8 weeks | ||||||
- ABA: not mentioned | ||||||
Negri et al. [ | Animal study on Wistar rats | Avulsion | CH-based paste* (8) | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: NS |
Sealapex (8) | - Surface treatment: 10 min in 2% acidulated phosphate sodium fluoride | - IRR: NS | ||||
Endofill (8) | - Splinting: none | |||||
- Sacrifice: 60 days | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Day et al. [ | Multicenter randomized controlled trial | Avulsion | CH (15 teeth/12 patients) | Delayed or immediate replantation | - Storage: a maximum of 20 min dry extra-alveolar storage time, or the aforementioned scenario plus a maximum of 60 min extra-alveolar time, kept in milk or another appropriate storage media | - Ankylosis: NS |
Ledermix (12 teeth/10 patients) | - RCT procedure: pulp extirpated and dressed with CH or Ledermix within 7–10 days, at days 60–90 re-dressed with CH, at month 6 obturated if no sign of active resorption, at year 1 definite diagnosis or patient continued to be reviewed until healing | - Periodontal healing: NS | ||||
- Splinting: 7–10 days | ||||||
- Clinical visits: 60–90 days, 6 months ± 14 days, 1 year ± 14 days | ||||||
- ABA: amoxicillin, if allergic another suitable antibiotic | ||||||
Thong et al. [ | Animal study on monkeys | Avulsion | Control (12) | Immediate replantation | - Storage: 15 min bench-dried | - Ankylosis: significantly lower in Ledermix group than in CH group (p < 0.05), but NS when the untreated control was compared with either treatment group |
CH (11) | - Surface treatment: none | - IRR: NS between CH and Ledermix, but significantly lower in both treatment groups than in the control group (p < 0.05) | ||||
Ledermix (12) | - Splinting: none | |||||
- Sacrifice: after 8 weeks | ||||||
- ABA: not mentioned | ||||||
Bryson et al. [ | Animal study on mongrel dogs | Avulsion | CH (15) | Delayed replantation | - Storage: 60 min bench-dried | - Favorable healing (presence of cementum over the dentin surface whether previously resorbed or not), and poor healing (including IRR or ankylosis): Ledermix exhibited a significantly greater amount of favorable healing (p = 0.004) |
Ledermix (14) | - Surface treatment: not mentioned | |||||
- Splinting: none | ||||||
- Sacrifice: 4 months | ||||||
- ABA: not mentioned | ||||||
Mori et al. [ | Animal study on Wistar rats | Avulsion | CH (15) | Delayed replantation | - Storage: 30 min bench-dried | - At 15 days: NS |
Alendronate (15) | - Surface treatment: 30 min in 1% hypochlorite solution and 20 min in 2% acidulated phosphate sodium fluoride | - At 30 days: IRR, RRR, and ankylosis were greater in the CH group (p < 0.05) | ||||
- Splinting: none | - At 60 days: NS | |||||
- Sacrifice: 15, 30, and 60 days | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Thong et al. [ | Animal study on monkeys | Avulsion | Control (plaque) (5) | Delayed replantation | - Storage: 60 min bench-dried | - Ankylosis: was the least in the control and the greatest in the bisphosphonate-treated group (p < 0.05); the difference was NS between the CH and bisphosphonate groups, but both had significantly higher ankylosis occurrence than the untreated control (p = 0.01) |
CH (7) | - Surface treatment: | - IRR: was significantly greater in the control than in the 2 treatment groups (p = 0.02), but was NS between the CH and bisphosphonate groups | ||||
Bisphosphonate (etidronate disodium) (11) | - Splinting: none | |||||
- Sacrifice: 8 weeks | ||||||
- ABA: not mentioned | ||||||
Mori et al. [ | Animal study on Wistar rats | Avulsion | CH | Delayed replantation | - Storage: 30 min bench-dried | - At 15 days: NS |
Acetazolamide solution | - Surface treatment: 30 min in 1% hypochlorite solution and 20 min in 2% acidulated phosphate sodium fluoride | - At 30 days: ankylosis and RRR were greater in the CH group (p < 0.05) | ||||
- Sacrifice: 15, 30, and 60 days | - At 60 days: RRR and IRR were greater in the CH group (p < 0.05) | |||||
- Splinting: none | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Mori et al. [ | Animal study on Wistar rats | Avulsion | CH | Delayed replantation | - Storage: 30 min bench-dried | - Ankylosis: NS |
Acetazolamide paste | - Surface treatment: 20 min in 1% hypochlorite solution and 20 min in 2% acidulated phosphate sodium fluoride | - RRR: at 60 days, was greater in the CH group (p < 0.05) | ||||
- Splinting: none | - IRR: NS | |||||
- Sacrifice: at 15 and 60 days | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
Zanetta-Barbosa et al. [ | Animal study on dogs | Avulsion | Control (6) | Delayed replantation | - Storage: 50 min bench-dried | - Ankylosis: NS |
CH (6) | - Surface treatment: 10 min in 0.9% physiologic saline, or CH solution (50 mg/mL), or indomethacin solution (50 mg/mL), or CH + indomethacin solution (25 mg/mL of each) | - IRR: NS | ||||
Indomethacin (6) | - Splinting 15 days | |||||
CH + indomethacin (6) | - Sacrifice: on day 120 | |||||
- ABA: single dose of penicillin G procaine 300,000 IU and sodium penicillin G 100,000 IU | ||||||
Mori et al. [ | Animal study on Wistar rats | Avulsion | CH | Delayed replantation | - Storage: 30 min bench-dried | - At 15 days: NS |
Gallium nitrate | - Surface treatment: 30 min in 1% hypochlorite solution and 20 min in 2% acidulated phosphate sodium fluoride | - At 30 days: ankylosis and RRR were greater in the CH group (p < 0.05) | ||||
- Splinting: none | - At 60 days: NS | |||||
- Sacrifice: at 15, 30, and 60 days | ||||||
- ABA: single IM dose of penicillin G benzathine 20,000 IU | ||||||
de Oliveira et al. [ | Animal study on Wistar rats | Avulsion | CH (8) | Delayed replantation | - Storage/surface treatment: 45 min in saturated solution of sodium chloride | - Emdogain-treated teeth showed a lower percentage of surface resorption (31.58%) than the CH group (80.48%) (p = 0.0006) |
Enamel Matrix-derived protein (Emdogain) (8) | - Splinting: not mentioned | |||||
- Sacrifice: 25 days | ||||||
- ABA: none |
Notation: in the studies performed by Mori et al. [
CH, calcium hydroxide; MTA, mineral aggregate trioxide; ABA, antibiotic administration; IU, international unit; IRR, inflammatory root resorption; RRR, replacement root resorption; NS, not significant; IM, intramuscular; RCT, root canal treatment.
*5 mL of propylene glycol, 5 g of CH, 2 g of zinc oxide, and 0.015 g of colophony.
Notation: in the studies performed by Mori et al. [
CH, calcium hydroxide; MTA, mineral aggregate trioxide; ABA, antibiotic administration; IU, international unit; IRR, inflammatory root resorption; RRR, replacement root resorption; NS, not significant; IM, intramuscular; RCT, root canal treatment.
*5 mL of propylene glycol, 5 g of CH, 2 g of zinc oxide, and 0.015 g of colophony.