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HOME > Restor Dent Endod > Volume 37(1); 2012 > Article
Research Article Effect of fluoride concentration in pH 4.3 and pH 7.0 supersaturated solutions on the crystal growth of hydroxyapatite
Haneol Shin, DDS1, Sung-Ho Park, DDS, MSD, PhD1, Jeong-Won Park, DDS, MSD, PhD2, Chan-Young Lee, DDS, MSD, DDSc1
2012;37(1):-23.
DOI: https://doi.org/10.5395/rde.2012.37.1.16
Published online: March 2, 2012

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Correspondence to Chan-Young Lee, DDS, MSD, DDSc. Professor, Department of Conservative Dentistry, Yonsei University College of Dentistry, 50 Yonsei-ro, Seodaemun-gu, Seoul, Korea 120-752. TEL, +82-2-2228-8701; FAX, +82-2-313-7575; chanyoungl@yuhs.ac
• Received: December 17, 2011   • Revised: January 13, 2012   • Accepted: January 20, 2012

©Copyights 2012. The Korean Academy of Conservative Dentistry.

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  • Objectives
    Present study was undertaken to investigate the crystal growth onto synthetic hydroxyapatite (HA) seeds in pH 4.3 and pH 7.0 supersaturated solutions with different fluoride concentrations.
  • Materials and Methods
    8 groups of pH 4.3 and 7.0 calcium phosphate supersaturated solutions were prepared with different fluoride concentrations (0, 1, 2 and 4 ppm). Calcium phosphate precipitates yield crystal growth onto the HA seed surface while solutions flow. For evaluation of crystallizing process, the changes of Ca2+, PO43-, F- concentrations of the inlet and outlet solutions were determined. The recovered solid samples were weighed to assess the amount of minerals precipitated, and finally determined their composition to deduce characteristics of crystals.
  • Results
    During the seeded crystal growth, there were significantly more consumption of Ca2+, PO43-, F- in pH 4.3 solutions than pH 7.0 (p < 0.05). As fluoride concentration increased in pH 4.3 solution, Ca2+, PO43-, F- consumption in experimental solutions, weight increment of HA seed, and fluoride ratio in crystallized samples were increased. There were significant differences among the groups (p < 0.05). But in pH 7.0 solution, these phenomena were not significant. In pH 7.0 solutions, analyses of crystallized samples showed higher Ca/P ratio in higher fluoride concentration. There were significant differences among the groups (p < 0.05). But in pH 4.3 solution, there were not significant differences in Ca/P ratio.
  • Conclusions
    Crystal growth in pH 4.3 solutions was superior to that in pH 7.0 solutions. In pH 4.3 solutions, crystal growth increased with showed in higher fluoride concentration up to 4 ppm.
  • Keywords: Fluoride concentration; Hydroxyapatite; pH; Seeded crystal growth
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Figure 1
Schematic illustration of experimental set-up.
rde-37-16-g001.jpg
Figure 2
Schematic illustrations of calculating the amounts of crystal growth. (a) Amounts of seed crystals oriinally placed in the reaction column; (b) Weighed amounts of solid sampe recovered at the end of experiment; (b)-(a) Difference between (b) and (a), amounts of crystal growth.
rde-37-16-g002.jpg
Table 1
Initial composition of experimental solutions
rde-37-16-i001.jpg
Table 2
Changes in compositions of the experimental solution after experiments (Mean ± SD, n = 10)

SD, standard deviation; NM, not measurable, no fluoride was added to the experimental solutions.

Different letters denote statistically different (p < 0.05).

rde-37-16-i002.jpg
Table 3
Weight increments of the HA seed after crystal growth (Mean ± SD, n = 10)

SD, standard deviation.

Different letters denote statistically different (p < 0.05).

rde-37-16-i003.jpg
Table 4
Molecular ratio in crystallized samples (Mean ± SD, n = 10)

SD, standard deviation.

*1 sample is missed in two groups (groups 6 and 8, n = 9).

Different letters denote statistically different (p < 0.05).

rde-37-16-i004.jpg

Tables & Figures

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    • Qualitative analysis on crystal growth of synthetic hydroxyapatite influenced by fluoride concentration
      Sumi Kang, Jeong Taeg Seo, Sung-Ho Park, Il Young Jung, Chan Young Lee, Jeong-Won Park
      Archives of Oral Biology.2019; 104: 52.     CrossRef

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      Effect of fluoride concentration in pH 4.3 and pH 7.0 supersaturated solutions on the crystal growth of hydroxyapatite
      Restor Dent Endod. 2012;37(1):16-23.   Published online March 2, 2012
      DOI: https://doi.org/10.5395/rde.2012.37.1.16
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    Effect of fluoride concentration in pH 4.3 and pH 7.0 supersaturated solutions on the crystal growth of hydroxyapatite
    Image Image
    Figure 1 Schematic illustration of experimental set-up.
    Figure 2 Schematic illustrations of calculating the amounts of crystal growth. (a) Amounts of seed crystals oriinally placed in the reaction column; (b) Weighed amounts of solid sampe recovered at the end of experiment; (b)-(a) Difference between (b) and (a), amounts of crystal growth.

    Figure 1

    Figure 2

    Effect of fluoride concentration in pH 4.3 and pH 7.0 supersaturated solutions on the crystal growth of hydroxyapatite

    Initial composition of experimental solutions

    Changes in compositions of the experimental solution after experiments (Mean ± SD, n = 10)

    SD, standard deviation; NM, not measurable, no fluoride was added to the experimental solutions.

    Different letters denote statistically different (p < 0.05).

    Weight increments of the HA seed after crystal growth (Mean ± SD, n = 10)

    SD, standard deviation.

    Different letters denote statistically different (p < 0.05).

    Molecular ratio in crystallized samples (Mean ± SD, n = 10)

    SD, standard deviation.

    *1 sample is missed in two groups (groups 6 and 8, n = 9).

    Different letters denote statistically different (p < 0.05).
    Table 1 Initial composition of experimental solutions

    Table 2 Changes in compositions of the experimental solution after experiments (Mean ± SD, n = 10)

    SD, standard deviation; NM, not measurable, no fluoride was added to the experimental solutions.

    Different letters denote statistically different (p < 0.05).

    Table 3 Weight increments of the HA seed after crystal growth (Mean ± SD, n = 10)

    SD, standard deviation.

    Different letters denote statistically different (p < 0.05).

    Table 4 Molecular ratio in crystallized samples (Mean ± SD, n = 10)

    SD, standard deviation.

    *1 sample is missed in two groups (groups 6 and 8, n = 9).

    Different letters denote statistically different (p < 0.05).

    Table 1

    Table 2

    Table 3

    Table 4

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